Jedem Tierchen sein Pläsierchen.
For me, its all about nest-building. And having an occasional huge firefight with a whole crew against a full company of enemies.
If you look for challenges by stronger opposition, use the improved raider and improved gunner mod. But dont complain, because these mods - well, improve them. Tougher armor. Stronger weapons. Bigger numbers. Strongholds of theirs. Once in a month I call all my ladies to arms and band of six that we are we come over Quincy and clean the place up again. These mods make it a gunner stronghold. There are then two dozens of them, or more, I am not certain, and they have good equipment. The party is usually extraordinarily hot.