Nice to know I'm not alone!
The new 1.5.x development wine works without problem, I added the ppa to software sources and that was it. In fact the biggest problem was uplay, not sh5 itself!
Now I've been playing sh5 for the last month, and even with all its incredible bugs and weird faults, I surrendered to the beautiful graphics and the boat's interior ambient.
You have to love all the modders!