jayTHREEpoint0 the main things that could cause problems that I remember are:
1. You need to run in admin mode for both the installation and when you run the game
2. If you are not using the default 16×9 you need to install the correct resolution module using the Generic Mod Enabler
This isn't an exhaustive list but they are the easiest to deal with. Win11 also causes problems for some people.