You can run just about any mission with or without LW/Ami. The main differences are going to be the detection ranges for sub contacts, the performance of various weapons, and the performance of AI platforms. That can make the mission easier or harder, depending on the circumstances.
In RSR, the most noticable change when using LW/Ami is the effectiveness of Helix helicopters, especially in Time on Target and Race of the Cripples. The runner-up is probably the Silex ASROC, in Nordic Hammer and again in Cripples. Those missions will be much harder with LW/Ami. On the other side, the FFG will have an easier time spoofing missiles in Opening Moves and Riposte, and the AI P-3 in Opening Moves is can be effectively tasked to investigate and prosecute contacts.
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