You can try and get a download version (NON-Steam), for example from Amazon, if you go through the link at the top of the forum's page.
There are quite a few things you going to be missing. But it is not even that - it is what out of the features, that were majorly broken and you are unable to fix w/o TDW Patcher you are ok with NOT-working.
The most obvious, of course, is use of stadimeter. I'm pretty sure there are some other fixes for it, that does not require the .exe patch, but as far as I know most of them haven't been used for a very long time and I'm not even sure if they are around.
The additional features are awasome, but they are useless if the main game is working only in a horrible way, don't you think?