The loss rate you mentioned of over 33% in that one mission is totally unsustainable in conventional war. So with losses like those, they'll get sortie rates reduced by virtue of
running out of fighters, either being shot down or held back to avoid a fruitless sacrifice. So, you have six aircraft taking off again. So far that's 22 sorties. With the original sixteen, so far that's-
1.4 (rounded up) sorties per plane per day so far.
Now let's assume the next mission goes completely smoothly. No losses, no damage. Then all six go out and strike again. 28 sorties, sixteen planes. 1.75 sorties per plane per day. At this point there's undeniable wear because this is a frenzied surge. Now if you look at
emsoy's post, the 1.75 I calculated is
lower than the surge ops rate for more modern fighters-undoubtedly skewed by the high losses in the first strike. This is for surge operations (frenzy-quick followed by a long cooldown). Deliberately planned offensive ops are a different story-during Vietnam, the
entire 7th Air Force often only managed one strike package a day in
ideal conditions. Anyhow, the devs have already said they want to give scenario designers the option of different ready times for different conditions.