[propbeanie]

With my 'modern' Win10 laptop, I have the Windows display settings the same as the "Native" resolution of the display monitor, and have the game set the same. I do not have a dual-card set-up like you though... but anyway, matching that, and then I right-click the SH4.exe file, and choose "Properties", and then the "Compatibility" tab. Just for SnGs, I chose "Run as an administrator" (it should not be necessary), since I was there, but the thing that helped it to actually function correctly was to click on the "Change high DPI settings", and I chose "High DPI scaling Overide - Overide high DPI scaling behavior. Scaling performed by: <Application>". That did the trick for my laptop.