My theory is that it's a combination of mods used and graphics/sound settings. I didn't really run into issues until I maxed everything out and started running TMO, RSRDC, OTC, and Trav's at 1600x900 60hz. I do that by enabling the OTC 16:9 last, btw. Seems to be working fine now but it would CTD every time I went to the bridge or looked through the scope outside the harbor at Pearl until I remembered to apply this.
I'm running Win 7 64 w/ 8 gb RAM. I got the game through Steam and the 4 gig patch wouldn't even try to work. Stumbling across this thread saved me a lot of trouble.
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