A thought that occurred to Me, that there is a very... very slim to none chance.. that LAA, if that is being used by woozle... of it losing its laser guided focus of where the .exe is located & thusly... of its guiding principle of clarity to Window's, of the fact that it is to be assigned the necessary, 4GB access pass.
Rare, but... it can & does occur.
Not sure if with the use of the 4GB patch, if that occurs... never having used said patch.
There is, in LAA, the ability to lock step the .exe into "brute force", using the lock in to, that SH4.exe's (or any other, for that matter, .exe of any other game.) being, for all intents & purposes of assignment of 4GB access. Not that means it will use all 4, just that it has the admin privilege to it. As is My understanding of that.
Is but a simple matter, to rerun LAA, & after pointing it or making sure that LAA is laser pointed at the .exe in question... to edit the link up to change the whole thing to a "forced" state.
Hope (as always) that this info is helpful.
M. M.