Where did you install the game, in other words, what is the path? ie: "C:\Progamr Files (x86)\Ubisoft etc..." or whatever. Refer to the mod's Support folder, specifically the "Install Notes For the Various Versions of SH4 in Windows.pdf" for detailed guidance.
While it's been a bit of time, refer also to CapnScurvy's
Windows10; Large Address Aware; SH4 Install posts and thread for Win10 specifics with SH4 and LAA.
