Is it possible for you to remove that hard drive on a temp basis and put it another PC of yours ; then scan? The advantage of doing that it is not a bootable drive which might confuse the virus/spyware and remove it or kill it using the temp PC? I have had a lot of luck using this approach avoiding a total reformat of the bum hard drive.
Of course you expose the other machine a SLIGHT risk of the same infection ... but... by making a suspected h.d. as a secondary drive, it is SO MUCH EASIER to clean it up than beating yours brains out if using it as the boot drive in the secondary PC.
Just a suggestion.
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Sink them all!
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