The UK government signs deals to buy 114 million more doses of the Pfizer and Moderna vaccines to use in 2022 and 2023
The deals were speeded up after the Omicron variant emerged - but talks were already under way.
Pfizer's boss tells the BBC that annual jabs "are likely to be needed" to maintain high levels of protection.
But the WHO points out that many poorer countries have still not been able to vaccinate their most vulnerable.
UK regulators approve new treatment that could reduce hospitalisation and death by 79% in high-risk adults.
Scientists in Cardiff meanwhile find the trigger for very rare blood clots after the Oxford-AZ jab.
On Wednesday, the UK recorded a further 48,374 coronavirus cases and another 171 deaths.
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