Cannot comment on Steam acchievements, dont care, dont even know what they are and what they do.
Anyhow, you could start a test game with mods you want to check out, and if you do not like it, you just load an older savegame from the previous match/strain. You could also load an old savegame from early in your current strain, if you want to skip the avatar setup sequence, do so with the mods active you want to check. If you do not like it, leave, swithc mod off in mod menu, and load your latest savegame, and you should be fine again. I did this a lot.
Just saying, I dont want to missionize you into something. Its just that you risk your soul's salvation if you don't do what I tell you.