i have not had much trouble in the single missions unless there are a lot of enemy ships that start shooting. when its one or two ships in the mission its not a big deal.
I run into issues more in the campaign when there are several escorts with a sub or two, torpedoes everywhere and always at least one or two get killed by their own friendly fire.
a recommendation i would make is when the mission is about to start and you have the "review XO orders option" you should be able to select a speed and a depth from there that you will start the mission out with.
that way it doesnt spawn you running 20 knots at 150 ft and your instantly a target
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