In theory it could - but in reality you wont see any noticable drop off. Though pushing 2+ year old transistors isnt likely to be the wisest choice, your more likely to pop em due to age than you are to run them as they are and see any significant performance reduction over the time frame.
Overclocking means as Firewall says - can you afford to replace it. Usually you wont hose it as long as you can clock it back down. But the chance remains.
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Good Hunting!
Captain Haplo
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