If you can afford it GO FOR IT!
The only reason I am saying that is GDDR5. That is insane!
Also the ATI cards have HDMI audio. Set it up right and you will get 7.1 LCPM (Lossless) audio going to the Amp. Then get a HDMI to DVI adapter and go from the HDMI out of the Amp and into the display.
Now of course this means you have to have an Amp that does all this. However, If you are considering such a card you likely have the funds to invest in an Amp.
BTW don't bother with a crossfire. Spend the money supporting a X2 and reduce the strain on the power supply and the power bill.
Check this out!
http://www.newegg.com/Product/Produc...82E16814121294